Screening Billions of Antibodies for Function in a Single Day
Innovative Targeting Solutions has taken nature’s most powerful diversity generating system and is applying it to make the world’s most potent biologics. The HuTARG™ technology’s appeal to scientists is that libraries of 10^9 or greater are generated de novo by the cell line so that manipulations of large synthetic libraries are no longer required. In addition, because HuTARG™ system is fully mammalian, the cell line itself can be engineered prior to library generation thus allowing the direct interrogation of cells expressing functional antibodies at the single-cell level. The convergence of these two processes allows functional assay screening to be done at an unprecedented scale (greater than 10^9 variants/day). It was this ability to simultaneously screen billions of variants for functional activity that allowed Innovative Targeting Solutions to discover the world’s first agonist antibody to the GLP1R.
Innovative Targeting Solutions Inc.